derangement
     n 1: a state of mental disturbance and disorientation [syn: {mental
          unsoundness}, {unbalance}]
     2: the act of disturbing the mind or body; "his carelessness
        could have caused an ecological upset"; "she was
        unprepared for this sudden overthrow of their normal way
        of living" [syn: {upset}, {overthrow}]
Source: WordNet® 2.0